Postdoctoral Researcher, Characterisation Scientist

Job title: Postdoctoral Researcher, Characterisation Scientist

Company:


Job description: Offer DescriptionRole SummaryIn collaboration with a leading biopharmaceutical manufacturer, this role will focus on optimisation of various aspects of the multi-attribute method (MAM) to deliver a robust solution using liquid chromatography coupled to high-resolution mass spectrometry that can be deployed within the routine testing environment. The role will identify, investigate and eliminate sources of variability during sample preparation that may cause unwanted modification of the therapeutics under study, which could otherwise skew the resulting analytical data. The role will require systematic approaches and meticulous attention to detail to provide a deep understanding into why such modifications on a therapeutic protein occur during sample preparation and then using that understanding to develop mitigation and elimination strategies to deliver a robust solution capable of consistent delivery of analytical data of the highest quality.Responsibilities

• You will investigate the root causes of unwanted sample preparation induced modifications on therapeutic proteins during standard workflows used prior to LC-MS based MAM. You will have a solid understanding of protein chemistry and apply that to develop mitigation and elimination strategies to avoid sample preparation induced modifications, delivering a robust solution that can be transferred into the routine testing environment.
• You will have experience in liquid chromatography mass spectrometry, ideally for therapeutic protein and peptide characterisation, and will become an expert in LC-MS MAM using high-resolution Orbitrap MS instruments including all aspects of operation, troubleshooting, maintenance and data processing.
• You will use other analytical instrumental approaches, for example, inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of trace elements or others as necessary to investigate root causes of modification.
• You will investigate how optimised workflows for sample preparation for MAM may be automated, again identifying, investigating and eliminating any potential source of sample preparation induced modification from the workflow.
• You will interact with the industrial sponsor with the highest levels of professionalism and use your project management skills to ensure that experiments are conducted, reported and disseminated according to the agreed project schedule.
• You’ll participate in the training and networking activities to ensure that you grow and develop as a scientist, both technically and professionally, bearing in mind that you will be an ambassador for NIBRT in all your activities.
• Create and maintain high quality documentation and you’ll actively publish and present your research outputs.
• Contribute to the on-going learning and success of the CCL team.
• Adhere and contribute to a safe research culture and one that operates with the highest integrity.

Where to apply E-mailcareers@nibrt.ieRequirementsResearch Field Chemistry » Analytical chemistry Education Level PhD or equivalentSkills/Qualifications

• You’ll be self-driven, passionate and committed to delivering robust solutions for the collaborative sponsor, motivated by inquisitiveness and excellent analytical rigour to understand key research challenges and develop appropriate solutions that directly translate into tangible impact.
• You understand the complexities of therapeutic protein characterisation, particularly peptide centred workflows and the intricacies of the use and application of LC-MS and subsequent data processing to deliver excellent analytical solutions.
• You have broad analytical awareness and including interest in the state-of-the-art and movements within the field, such as automation and integration of workflows.
• You’re a passionate communicator who is well able to articulate their science using written and verbal English to specialist and non-specialist audiences.
• You’re hardworking, you embrace challenges and you’re motivated by the situations and environment that you find yourself in to do excellent research and deliver impactful science.
• You’re curious and ambitious, you have a track record of proposing and performing excellent analytical science which drives you to achieve. You can actively demonstrate this through your publication record to date.
• You have excellent self-awareness; you can adapt and maintain focus and composure when research poses its challenges.
• You’re a standout teammate, you see and believe in the bigger picture for the wider group, you hold yourself and others accountable to results and you’re committed to achieve.
• You hold a PhD or have submitted a doctoral thesis for examination in a discipline that makes you suitable for this challenge during which the use and application of mass spectrometry instrumentation played a major component.

Additional InformationBenefitsCompetitive salary and excellent suite of benefits including pension, private health insurance, income protection scheme, 25 days annual leave plus up to 3 additional company days off, generous training and career development supports, flexible working hours and work from home set up supported.Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute NIBRT Country Ireland City Dublin GeofieldContact CityDublin WebsiteStreetFosters Avenue E-Mailcareers@nibrt.ieSTATUS: EXPIREDShare this page

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Location: Dublin

Job date: Sun, 15 Jun 2025 06:49:47 GMT

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